mCRC: Möglichst oft Resektabilität erreichen

OFT—Objectives and Concepts

The research work carried out within the OFT-project shall provide insights, methods, and prototypic software to support the design of hydraulic closed loop control systems. The paper in hand presents an overview of the research work, motivates the current objectives of the project, and provides useful background information. In particular we develop different views of the hydraulic design proc...

Oft, Vbp: Qed?

The report by the Office of Fair Trading (OFT) on the UK pharmaceutical price regulation scheme (PPRS) recommends the reform of the current scheme, which is a combination of profit and price controls, to one where price is based on the health benefits offered by a pharmaceutical. On closer examination some of the more commonly expressed concerns about these proposals do not seem to be well foun...

Optimal Foraging Theory - OFT

Unexpected side effect in mCRC

RATIONALE Regorafenib represents a treatment option in heavily pretreated patients affected by metastatic colorectal cancer (mCRC). Its safety profile is typical of small-molecule tyrosine-kinase inhibitors (TKIs) and most adverse events are manageable. PATIENT CONCERNS A 56 years-old Caucasian man affected by mCRC with normal hepatic reserve was treated with regorafenib as second-line treatm...

A Critique oft e Myths